The p53 tumor suppressor regulates AKR1B1 expression, a metastasis-promoting gene in breast cancer

Alteration of metabolism in cancer cells is a central aspect of the mechanisms that sustain aggressive traits. Aldo–keto reductase 1 B1 (AKR1B1) catalyzes the reduction of several aldehydes to alcohols consuming NADPH. Nevertheless, the ability of AKR1B1 to reduce different substrates renders diffic...

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Detalles Bibliográficos
Autores principales: Di Benedetto, Carolina, Borini Etichetti, Carla, Cocordano, Nabila, Cantoia, Alejo, Arel Zalazar, Evelyn, Bicciato, Silvio, Menacho-Márquez, Mauricio, Rosano, Germán Leandro, Girardini, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538543/
https://www.ncbi.nlm.nih.gov/pubmed/37780210
http://dx.doi.org/10.3389/fmolb.2023.1145279

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538543/
https://www.ncbi.nlm.nih.gov/pubmed/37780210
http://dx.doi.org/10.3389/fmolb.2023.1145279

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