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The p53 tumor suppressor regulates AKR1B1 expression, a metastasis-promoting gene in breast cancer
Alteration of metabolism in cancer cells is a central aspect of the mechanisms that sustain aggressive traits. Aldo–keto reductase 1 B1 (AKR1B1) catalyzes the reduction of several aldehydes to alcohols consuming NADPH. Nevertheless, the ability of AKR1B1 to reduce different substrates renders diffic...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538543/ https://www.ncbi.nlm.nih.gov/pubmed/37780210 http://dx.doi.org/10.3389/fmolb.2023.1145279 |