The development of resistance to an inhibitor of a cellular protein reveals a critical interaction between the enterovirus protein 2C and a small GTPase Arf1

The cellular protein GBF1, an activator of Arf GTPases (ArfGEF: Arf guanine nucleotide exchange factor), is recruited to the replication organelles of enteroviruses through interaction with the viral protein 3A, and its ArfGEF activity is required for viral replication, however how GBF1-dependent Ar...

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Detalles Bibliográficos
Autores principales: Viktorova, Ekaterina G., Gabaglio, Samuel, Moghimi, Seyedehmahsa, Zimina, Anna, Wynn, Bridge G., Sztul, Elizabeth, Belov, George A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538752/
https://www.ncbi.nlm.nih.gov/pubmed/37721955
http://dx.doi.org/10.1371/journal.ppat.1011673

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10538752/
https://www.ncbi.nlm.nih.gov/pubmed/37721955
http://dx.doi.org/10.1371/journal.ppat.1011673

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