Targeting the A3 adenosine receptor to treat hepatocellular carcinoma: anti-cancer and hepatoprotective effects

The A3 adenosine receptor (A3AR) is over-expressed in human hepatocellular carcinoma (HCC) cells. Namodenoson, an A3AR agonist, induces de-regulation of the Wnt and NF-kB signaling pathways resulting in apoptosis of HCC cells. In a phase I healthy volunteer study and in a phase I/II study in patient...

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Detalles Bibliográficos
Autores principales: Fishman, Pnina, Stemmer, Salomon M., Bareket-Samish, Avital, Silverman, Michael H., Kerns, William D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539266/
https://www.ncbi.nlm.nih.gov/pubmed/36781824
http://dx.doi.org/10.1007/s11302-023-09925-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539266/
https://www.ncbi.nlm.nih.gov/pubmed/36781824
http://dx.doi.org/10.1007/s11302-023-09925-2

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