Safety, Pharmacokinetics and Preliminary Efficacy of IL4-Rα Monoclonal Antibody AK120 in Both Healthy and Atopic Dermatitis Subjects: A Phase I, Randomized, Two-Part, Double-Blind, Placebo-Controlled, Dose-Escalation, First-In-Human Clinical Study

INTRODUCTION: Interleukin-4 (IL-4) and interleukin-13 (IL-13) are two essential cytokines involved in the T helper 2 (Th2)-mediated inflammatory response to diseases, such as atopic dermatitis (AD). AK120 is a humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody (mAb) directed against th...

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Detalles Bibliográficos
Autores principales: Wynne, Christopher John, Cole, Alexandra, Lemech, Charlotte, Wang, Guoqin, Zhang, Yu, Chen, Benchao, Wang, Max, Li, Baiyong, Xia, Michelle, Sinclair, Rodney
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539271/
https://www.ncbi.nlm.nih.gov/pubmed/37668898
http://dx.doi.org/10.1007/s13555-023-01010-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539271/
https://www.ncbi.nlm.nih.gov/pubmed/37668898
http://dx.doi.org/10.1007/s13555-023-01010-1

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