Structure of the human ATAD2 AAA+ histone chaperone reveals mechanism of regulation and inter-subunit communication

ATAD2 is a non-canonical ATP-dependent histone chaperone and a major cancer target. Despite widespread efforts to design drugs targeting the ATAD2 bromodomain, little is known about the overall structural organization and regulation of ATAD2. Here, we present the 3.1 Å cryo-EM structure of human ATA...

Descripción completa

Detalles Bibliográficos
Autores principales: Cho, Carol, Ganser, Christian, Uchihashi, Takayuki, Kato, Koichi, Song, Ji-Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539301/
https://www.ncbi.nlm.nih.gov/pubmed/37770645
http://dx.doi.org/10.1038/s42003-023-05373-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539301/
https://www.ncbi.nlm.nih.gov/pubmed/37770645
http://dx.doi.org/10.1038/s42003-023-05373-1

Ejemplares similares