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Structure of the human ATAD2 AAA+ histone chaperone reveals mechanism of regulation and inter-subunit communication
ATAD2 is a non-canonical ATP-dependent histone chaperone and a major cancer target. Despite widespread efforts to design drugs targeting the ATAD2 bromodomain, little is known about the overall structural organization and regulation of ATAD2. Here, we present the 3.1 Å cryo-EM structure of human ATA...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539301/ https://www.ncbi.nlm.nih.gov/pubmed/37770645 http://dx.doi.org/10.1038/s42003-023-05373-1 |