A virus-like particle-based bivalent PCSK9 vaccine lowers LDL-cholesterol levels in non-human primates

Elevated low-density lipoprotein cholesterol (LDL-C) is an important risk factor in the development of atherosclerotic cardiovascular disease (ASCVD). Inhibitors of proprotein convertase subtilisin/kexin type 9 (PCSK9), a negative regulator of LDL-C metabolism, have emerged as promising approaches f...

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Detalles Bibliográficos
Autores principales: Fowler, Alexandra, Van Rompay, Koen K. A., Sampson, Maureen, Leo, Javier, Watanabe, Jennifer K., Usachenko, Jodie L., Immareddy, Ramya, Lovato, Debbie M., Schiller, John T., Remaley, Alan T., Chackerian, Bryce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539315/
https://www.ncbi.nlm.nih.gov/pubmed/37770440
http://dx.doi.org/10.1038/s41541-023-00743-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539315/
https://www.ncbi.nlm.nih.gov/pubmed/37770440
http://dx.doi.org/10.1038/s41541-023-00743-6

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