Crystal structures and molecular dynamics simulations of a humanised antibody fragment at acidic to basic pH

Antibody-fragment (Fab) therapy development has the potential to be accelerated by computational modelling and simulations that predict their target binding, stability, formulation, manufacturability, and the impact of further protein engineering. Such approaches are currently predicated on starting...

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Detalles Bibliográficos
Autores principales: Tang, Jiazhi, Zhang, Cheng, Castillo, Nuria Codina, Lalaurie, Christophe J., Gao, Xin, Dalby, Paul A., Kozielski, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539359/
https://www.ncbi.nlm.nih.gov/pubmed/37770469
http://dx.doi.org/10.1038/s41598-023-42698-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539359/
https://www.ncbi.nlm.nih.gov/pubmed/37770469
http://dx.doi.org/10.1038/s41598-023-42698-7

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