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Crystal structures and molecular dynamics simulations of a humanised antibody fragment at acidic to basic pH
Antibody-fragment (Fab) therapy development has the potential to be accelerated by computational modelling and simulations that predict their target binding, stability, formulation, manufacturability, and the impact of further protein engineering. Such approaches are currently predicated on starting...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539359/ https://www.ncbi.nlm.nih.gov/pubmed/37770469 http://dx.doi.org/10.1038/s41598-023-42698-7 |