Recognition and cleavage mechanism of intron-containing pre-tRNA by human TSEN endonuclease complex

Removal of introns from transfer RNA precursors (pre-tRNAs) occurs in all living organisms. This is a vital phase in the maturation and functionality of tRNA. Here we present a 3.2 Å-resolution cryo-EM structure of an active human tRNA splicing endonuclease complex bound to an intron-containing pre-...

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Detalles Bibliográficos
Autores principales: Yuan, Ling, Han, Yaoyao, Zhao, Jiazheng, Zhang, Yixiao, Sun, Yadong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539383/
https://www.ncbi.nlm.nih.gov/pubmed/37770519
http://dx.doi.org/10.1038/s41467-023-41845-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539383/
https://www.ncbi.nlm.nih.gov/pubmed/37770519
http://dx.doi.org/10.1038/s41467-023-41845-y

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