MRTF-A gain-of-function in mice impairs homeostatic renewal of the intestinal epithelium

The actin-regulated transcription factor MRTF-A represents a central relay in mechanotransduction and controls a subset of SRF-dependent target genes. However, gain-of-function studies in vivo are lacking. Here we characterize a conditional MRTF-A transgenic mouse model. While MRTF-A gain-of-functio...

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Detalles Bibliográficos
Autores principales: Singh, Anurag Kumar, Rai, Amrita, Weber, Anja, Gericke, Martin, Janssen, Klaus-Peter, Moser, Markus, Posern, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539384/
https://www.ncbi.nlm.nih.gov/pubmed/37770456
http://dx.doi.org/10.1038/s41419-023-06158-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539384/
https://www.ncbi.nlm.nih.gov/pubmed/37770456
http://dx.doi.org/10.1038/s41419-023-06158-4

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