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CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth
The mammalian target of rapamycin complex1 (mTORC1) is a central regulator of metabolism and cell growth by sensing diverse environmental signals, including amino acids. The GATOR2 complex is a key component linking amino acid signals to mTORC1. Here, we identify protein arginine methyltransferase 1...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539482/ https://www.ncbi.nlm.nih.gov/pubmed/36995937 http://dx.doi.org/10.1016/j.celrep.2023.112316 |