iPSC-derived type IV collagen α5-expressing kidney organoids model Alport syndrome

Alport syndrome (AS) is a hereditary glomerulonephritis caused by COL4A3, COL4A4 or COL4A5 gene mutations and characterized by abnormalities of glomerular basement membranes (GBMs). Due to a lack of curative treatments, the condition proceeds to end-stage renal disease even in adolescents. Hampering...

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Detalles Bibliográficos
Autores principales: Hirayama, Ryuichiro, Toyohara, Kosuke, Watanabe, Kei, Otsuki, Takeya, Araoka, Toshikazu, Mae, Shin-Ichi, Horinouchi, Tomoko, Yamamura, Tomohiko, Okita, Keisuke, Hotta, Akitsu, Iijima, Kazumoto, Nozu, Kandai, Osafune, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539496/
https://www.ncbi.nlm.nih.gov/pubmed/37770589
http://dx.doi.org/10.1038/s42003-023-05203-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539496/
https://www.ncbi.nlm.nih.gov/pubmed/37770589
http://dx.doi.org/10.1038/s42003-023-05203-4

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