Computational remodeling of an enzyme conformational landscape for altered substrate selectivity

Structural plasticity of enzymes dictates their function. Yet, our ability to rationally remodel enzyme conformational landscapes to tailor catalytic properties remains limited. Here, we report a computational procedure for tuning conformational landscapes that is based on multistate design of hinge...

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Detalles Bibliográficos
Autores principales: St-Jacques, Antony D., Rodriguez, Joshua M., Eason, Matthew G., Foster, Scott M., Khan, Safwat T., Damry, Adam M., Goto, Natalie K., Thompson, Michael C., Chica, Roberto A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539519/
https://www.ncbi.nlm.nih.gov/pubmed/37770431
http://dx.doi.org/10.1038/s41467-023-41762-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539519/
https://www.ncbi.nlm.nih.gov/pubmed/37770431
http://dx.doi.org/10.1038/s41467-023-41762-0

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