p53 and MYC-regulated squalene epoxidase as Achilles heel in colorectal cancer

The transcription factors p53 and MYC are often considered non-druggable targets, but their dysregulation can generate new dependencies and treatment opportunities in cancer cells. The p53 and MYC-regulated squalene epoxidase (SQLE) has been identified as a potential Achilles heel in colorectal canc...

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Detalles Bibliográficos
Autor principal: Fischer, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539706/
https://www.ncbi.nlm.nih.gov/pubmed/37781510
http://dx.doi.org/10.7150/ijbs.89237
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author Fischer, Martin
author_facet Fischer, Martin
author_sort Fischer, Martin
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description The transcription factors p53 and MYC are often considered non-druggable targets, but their dysregulation can generate new dependencies and treatment opportunities in cancer cells. The p53 and MYC-regulated squalene epoxidase (SQLE) has been identified as a potential Achilles heel in colorectal cancer. This is of great interest because the FDA-approved anti-fungal SQLE inhibitor Terbinafine could be repurposed to treat colorectal cancer patients.
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spelling pubmed-105397062023-09-30 p53 and MYC-regulated squalene epoxidase as Achilles heel in colorectal cancer Fischer, Martin Int J Biol Sci Commentary The transcription factors p53 and MYC are often considered non-druggable targets, but their dysregulation can generate new dependencies and treatment opportunities in cancer cells. The p53 and MYC-regulated squalene epoxidase (SQLE) has been identified as a potential Achilles heel in colorectal cancer. This is of great interest because the FDA-approved anti-fungal SQLE inhibitor Terbinafine could be repurposed to treat colorectal cancer patients. Ivyspring International Publisher 2023-09-04 /pmc/articles/PMC10539706/ /pubmed/37781510 http://dx.doi.org/10.7150/ijbs.89237 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Commentary
Fischer, Martin
p53 and MYC-regulated squalene epoxidase as Achilles heel in colorectal cancer
title p53 and MYC-regulated squalene epoxidase as Achilles heel in colorectal cancer
title_full p53 and MYC-regulated squalene epoxidase as Achilles heel in colorectal cancer
title_fullStr p53 and MYC-regulated squalene epoxidase as Achilles heel in colorectal cancer
title_full_unstemmed p53 and MYC-regulated squalene epoxidase as Achilles heel in colorectal cancer
title_short p53 and MYC-regulated squalene epoxidase as Achilles heel in colorectal cancer
title_sort p53 and myc-regulated squalene epoxidase as achilles heel in colorectal cancer
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539706/
https://www.ncbi.nlm.nih.gov/pubmed/37781510
http://dx.doi.org/10.7150/ijbs.89237
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