Loss of DDRGK1 impairs IRE1α UFMylation in spondyloepiphyseal dysplasia

Spondyloepiphyseal dysplasia (SEMD) is a rare disease in which cartilage growth is disrupted, and the DDRGK1 mutation is one of the causative genes. In our study, we established Ddrgk1(fl/fl), Col2a1-ERT Cre mice, which showed a thickened hypertrophic zone (HZ) in the growth plate, simulating the pr...

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Detalles Bibliográficos
Autores principales: Yang, Xiao, Zhou, Tangjun, Wang, Xin, Xia, Ying, Cao, Xiankun, Cheng, Xiaofei, Cao, Yu, Ma, Peixiang, Ma, Hui, Qin, An, Zhao, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539710/
https://www.ncbi.nlm.nih.gov/pubmed/37781516
http://dx.doi.org/10.7150/ijbs.82765

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539710/
https://www.ncbi.nlm.nih.gov/pubmed/37781516
http://dx.doi.org/10.7150/ijbs.82765

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