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Four-dimensional NOE-NOE spectroscopy of SARS-CoV-2 Main Protease to facilitate resonance assignment and structural analysis

Resonance assignment and structural studies of larger proteins by nuclear magnetic resonance (NMR) can be challenging when exchange broadening, multiple stable conformations, and [Formula: see text] H back-exchange of the fully deuterated chain pose problems. These difficulties arise for the SARS-Co...

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Detalles Bibliográficos
Autores principales: Robertson, Angus J., Ying, Jinfa, Bax, Ad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Copernicus GmbH 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539749/
https://www.ncbi.nlm.nih.gov/pubmed/37904772
http://dx.doi.org/10.5194/mr-2-129-2021