High-affinity tamoxifen analogues retain extensive positional disorder when bound to calmodulin

Using a combination of NMR and fluorescence measurements, we have investigated the structure and dynamics of the complexes formed between calcium-loaded calmodulin (CaM) and the potent breast cancer inhibitor idoxifene, a derivative of tamoxifen. High-affinity binding ( [Formula: see text]  nM) satu...

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Detalles Bibliográficos
Autores principales: Milanesi, Lilia, Trevitt, Clare R., Whitehead, Brian, Hounslow, Andrea M., Tomas, Salvador, Hosszu, Laszlo L. P., Hunter, Christopher A., Waltho, Jonathan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Copernicus GmbH 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539762/
https://www.ncbi.nlm.nih.gov/pubmed/37905217
http://dx.doi.org/10.5194/mr-2-629-2021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539762/
https://www.ncbi.nlm.nih.gov/pubmed/37905217
http://dx.doi.org/10.5194/mr-2-629-2021

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