Rapid assessment of Watson–Crick to Hoogsteen exchange in unlabeled DNA duplexes using high-power SELOPE imino (1)H CEST

In duplex DNA, Watson–Crick A–T and G–C base pairs (bp's) exist in dynamic equilibrium with an alternative Hoogsteen conformation, which is low in abundance and short-lived. Measuring how the Hoogsteen dynamics varies across different DNA sequences, structural contexts and physiological conditi...

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Detalles Bibliográficos
Autores principales: Liu, Bei, Rangadurai, Atul, Shi, Honglue, Al-Hashimi, Hashim M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Copernicus GmbH 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539785/
https://www.ncbi.nlm.nih.gov/pubmed/37905209
http://dx.doi.org/10.5194/mr-2-715-2021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539785/
https://www.ncbi.nlm.nih.gov/pubmed/37905209
http://dx.doi.org/10.5194/mr-2-715-2021

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