Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling

Dishevelled (Dvl) proteins are important regulators of the Wnt signalling pathway, interacting through their PDZ domains with the Wnt receptor Frizzled. Blocking the Dvl PDZ–Frizzled interaction represents a potential approach for cancer treatment, which stimulated the identification of small-molecu...

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Detalles Bibliográficos
Autores principales: Kamdem, Nestor, Roske, Yvette, Kovalskyy, Dmytro, Platonov, Maxim O., Balinskyi, Oleksii, Kreuchwig, Annika, Saupe, Jörn, Fang, Liang, Diehl, Anne, Schmieder, Peter, Krause, Gerd, Rademann, Jörg, Heinemann, Udo, Birchmeier, Walter, Oschkinat, Hartmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Copernicus GmbH 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539800/
https://www.ncbi.nlm.nih.gov/pubmed/37904770
http://dx.doi.org/10.5194/mr-2-355-2021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539800/
https://www.ncbi.nlm.nih.gov/pubmed/37904770
http://dx.doi.org/10.5194/mr-2-355-2021

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