Cargando…

Increasing glutathione levels by a novel posttranslational mechanism inhibits neuronal hyperexcitability

Glutathione (GSH) depletion, and impaired redox homeostasis have been observed in experimental animal models and patients with epilepsy. Pleiotropic strategies that elevate GSH levels via transcriptional regulation have been shown to significantly decrease oxidative stress and seizure frequency, inc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sri Hari, Ashwini, Banerji, Rajeswari, Liang, Li-Ping, Fulton, Ruth E., Huynh, Christopher Quoc, Fabisiak, Timothy, McElroy, Pallavi Bhuyan, Roede, James R., Patel, Manisha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10539966/ https://www.ncbi.nlm.nih.gov/pubmed/37769522 http://dx.doi.org/10.1016/j.redox.2023.102895

Ejemplares similares

Effects of astrocytic mechanisms on neuronal hyperexcitability
por: Grigorovsky, Vasily, et al.
Publicado: (2014)

Causes and Consequences of Hyperexcitation in Central Clock Neurons
por: Diekman, Casey O., et al.
Publicado: (2013)

Enhancing glucose metabolism via gluconeogenesis is therapeutic in a zebrafish model of Dravet syndrome
por: Banerji, Rajeswari, et al.
Publicado: (2021)

The Contradictory Effects of Neuronal Hyperexcitation on Adult Hippocampal Neurogenesis
por: Pineda, José R., et al.
Publicado: (2016)

Hyperexcitability of Sensory Neurons in Fragile X Mouse Model
por: Deng, Pan-Yue, et al.
Publicado: (2021)

Neuronal hyperexcitability in the ventral posterior thalamus of neuropathic rats: modality selective effects of pregabalin
por: Patel, Ryan, et al.
Publicado: (2016)

Mechanisms Driving the Emergence of Neuronal Hyperexcitability in Fragile X Syndrome
por: Bülow, Pernille, et al.
Publicado: (2022)

The differential response to neuronal hyperexcitation and neuroinflammation of the hippocampal neurogenic niche
por: Ruiz-Clavijo, Lorena, et al.
Publicado: (2023)

The Role of Hyperexcitability in Gliomagenesis
por: Goethe, Eric A., et al.
Publicado: (2023)

Spinal muscular atrophy patient-derived motor neurons exhibit hyperexcitability
por: Liu, Huisheng, et al.
Publicado: (2015)

Neuronal hyperexcitability in Alzheimer’s disease: what are the drivers behind this aberrant phenotype?
por: Targa Dias Anastacio, Helena, et al.
Publicado: (2022)

Increased degradation of FMRP contributes to neuronal hyperexcitability in tuberous sclerosis complex
por: Winden, Kellen D., et al.
Publicado: (2023)

Crosstalk between neuroinflammation and oxidative stress in epilepsy
por: Fabisiak, Timothy, et al.
Publicado: (2022)

Reduced Function of the Glutathione S-Transferase S1 Suppresses Behavioral Hyperexcitability in Drosophila Expressing Mutant Voltage-Gated Sodium Channels
por: Chen, Hung-Lin, et al.
Publicado: (2020)

Posttranslational Modifications of Tubulin and the Polarized Transport of Kinesin-1 in Neurons
por: Hammond, Jennetta W., et al.
Publicado: (2010)

Novel Mutations in Synaptic Transmission Genes Suppress Neuronal Hyperexcitation in Caenorhabditis elegans
por: McCulloch, Katherine A., et al.
Publicado: (2017)

Ion channels and neuronal hyperexcitability in chemotherapy-induced peripheral neuropathy: Cause and effect?
por: Aromolaran, Kelly A, et al.
Publicado: (2017)

Paradoxical neuronal hyperexcitability in a mouse model of mitochondrial pyruvate import deficiency
por: De La Rossa, Andres, et al.
Publicado: (2022)

Neocortical localization and thalamocortical modulation of neuronal hyperexcitability contribute to Fragile X Syndrome
por: Pedapati, Ernest V., et al.
Publicado: (2022)

Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex
por: Wu, Xiaoping, et al.
Publicado: (2022)

Mosaic and non-mosaic protocadherin 19 mutation leads to neuronal hyperexcitability in zebrafish
por: Robens, Barbara K., et al.
Publicado: (2022)

Cortical neuronal hyperexcitability and synaptic changes in SGCE mutation-positive myoclonus dystonia
por: Sperandeo, Alessandra, et al.
Publicado: (2022)

Tau in cerebrospinal fluid induces neuronal hyperexcitability and alters hippocampal theta oscillations
por: Brown, Jessica, et al.
Publicado: (2023)

Paradoxical Hyperexcitability in Disorders of Neurodevelopment
por: Antoine, Michelle W.
Publicado: (2022)

Organophosphorus diisopropylfluorophosphate (DFP) intoxication in zebrafish larvae causes behavioral defects, neuronal hyperexcitation and neuronal death
por: Brenet, Alexandre, et al.
Publicado: (2020)

Posttranslational Chemical Mutagenesis Methods to Insert Posttranslational Modifications into Recombinant Proteins
por: Harel, Omer, et al.
Publicado: (2022)

Altered Chloride Homeostasis Decreases the Action Potential Threshold and Increases Hyperexcitability in Hippocampal Neurons
por: Sørensen, Andreas T., et al.
Publicado: (2018)

Duloxetine Protects against Oxaliplatin-Induced Neuropathic Pain and Spinal Neuron Hyperexcitability in Rodents
por: Kim, Woojin, et al.
Publicado: (2017)

Cyclic nucleotide signaling in sensory neuron hyperexcitability and chronic pain after nerve injury
por: Li, Ze-Hua, et al.
Publicado: (2019)

SIK3 suppresses neuronal hyperexcitability by regulating the glial capacity to buffer K(+) and water
por: Li, Hailun, et al.
Publicado: (2019)

Neuronal Hyperexcitability and Free Radical Toxicity in Amyotrophic Lateral Sclerosis: Established and Future Targets
por: Shibuya, Kazumoto, et al.
Publicado: (2022)

ACVR1-activating mutation causes neuropathic pain and sensory neuron hyperexcitability in humans
por: Yu, Xiaobing, et al.
Publicado: (2023)

Posttranslational Modifications in Ferroptosis
por: Wei, Xiang, et al.
Publicado: (2020)

A Theoretical Study on the Role of Astrocytic Activity in Neuronal Hyperexcitability by a Novel Neuron-Glia Mass Model
por: Garnier, Aurélie, et al.
Publicado: (2016)

Corticomotoneuronal function and hyperexcitability in acquired neuromyotonia
por: Vucic, Steve, et al.
Publicado: (2010)

Neural Hyperexcitability in Autism Spectrum Disorders
por: Takarae, Yukari, et al.
Publicado: (2017)

Sulfasalazine decreases mouse cortical hyperexcitability
por: Alcoreza, Oscar, et al.
Publicado: (2019)

Hyperexcitability and Homeostasis in Fragile X Syndrome
por: Liu, Xiaopeng, et al.
Publicado: (2022)

Ripples of Hyperexcitability in Epilepsy, Autism, and Inattention
por: Salpekar, Jay A.
Publicado: (2023)

Formalin-induced behavioural hypersensitivity and neuronal hyperexcitability are mediated by rapid protein synthesis at the spinal level
por: Asante, Curtis O, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_ddtp4odb8ogrurtjgop8p81pfn