Immunogenic epitope scanning in bacteriolytic enzymes Pal and Cpl-1 and engineering Pal to escape antibody responses

Bacteriolytic enzymes are promising antibacterial agents, but they can cause a typical immune response in vivo. In this study, we used a targeted modification method for two antibacterial endolysins, Pal and Cpl-1. We identified the key immunogenic amino acids, and designed and tested new, bacteriol...

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Detalles Bibliográficos
Autores principales: Harhala, Marek Adam, Gembara, Katarzyna, Rybicka, Izabela, Kaźmierczak, Zuzanna Maria, Miernikiewicz, Paulina, Majewska, Joanna Marta, Budziar, Wiktoria, Nasulewicz-Goldeman, Anna, Nelson, Daniel C., Owczarek, Barbara, Dąbrowska, Krystyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540205/
https://www.ncbi.nlm.nih.gov/pubmed/37781366
http://dx.doi.org/10.3389/fimmu.2023.1075774

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540205/
https://www.ncbi.nlm.nih.gov/pubmed/37781366
http://dx.doi.org/10.3389/fimmu.2023.1075774

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