Oxamate enhances the efficacy of CAR-T therapy against glioblastoma via suppressing ectonucleotidases and CCR8 lactylation

BACKGROUND: Chimeric antigen receptor (CAR)-T immunotherapy fails to treat solid tumors due in part to immunosuppressive microenvironment. Excess lactate produced by tumor glycolysis increases CAR-T immunosuppression. The mechanism of lactate inducing the formation of immunosuppressive microenvironm...

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Detalles Bibliográficos
Autores principales: Sun, Ting, Liu, Bin, Li, Yanyan, Wu, Jie, Cao, Yufei, Yang, Shuangyu, Tan, Huiling, Cai, Lize, Zhang, Shiqi, Qi, Xinyue, Yu, Dingjia, Yang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540361/
https://www.ncbi.nlm.nih.gov/pubmed/37770937
http://dx.doi.org/10.1186/s13046-023-02815-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540361/
https://www.ncbi.nlm.nih.gov/pubmed/37770937
http://dx.doi.org/10.1186/s13046-023-02815-w

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