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Oxamate enhances the efficacy of CAR-T therapy against glioblastoma via suppressing ectonucleotidases and CCR8 lactylation
BACKGROUND: Chimeric antigen receptor (CAR)-T immunotherapy fails to treat solid tumors due in part to immunosuppressive microenvironment. Excess lactate produced by tumor glycolysis increases CAR-T immunosuppression. The mechanism of lactate inducing the formation of immunosuppressive microenvironm...
Autores principales: | Sun, Ting, Liu, Bin, Li, Yanyan, Wu, Jie, Cao, Yufei, Yang, Shuangyu, Tan, Huiling, Cai, Lize, Zhang, Shiqi, Qi, Xinyue, Yu, Dingjia, Yang, Wei |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540361/ https://www.ncbi.nlm.nih.gov/pubmed/37770937 http://dx.doi.org/10.1186/s13046-023-02815-w |
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