Stable isotope labeling and ultra-high-resolution NanoSIMS imaging reveal alpha-synuclein-induced changes in neuronal metabolism in vivo

In Parkinson’s disease, pathogenic factors such as the intraneuronal accumulation of the protein α-synuclein affect key metabolic processes. New approaches are required to understand how metabolic dysregulations cause degeneration of vulnerable subtypes of neurons in the brain. Here, we apply correl...

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Detalles Bibliográficos
Autores principales: Spataro, Sofia, Maco, Bohumil, Escrig, Stéphane, Jensen, Louise, Polerecky, Lubos, Knott, Graham, Meibom, Anders, Schneider, Bernard L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540389/
https://www.ncbi.nlm.nih.gov/pubmed/37770947
http://dx.doi.org/10.1186/s40478-023-01608-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540389/
https://www.ncbi.nlm.nih.gov/pubmed/37770947
http://dx.doi.org/10.1186/s40478-023-01608-8

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