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Age-associated sex difference in the expression of mitochondria-based redox sensitive proteins and effect of pioglitazone in nonhuman primate brain

BACKGROUND: Paraoxonase 2 (PON2) and neuronal uncoupling proteins (UCP4 and UCP5) possess antioxidant, anti-apoptotic activities and minimize accumulation of reactive oxygen species in mitochondria. While age and sex are risk factors for several disorders that are linked with oxidative stress, no st...

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Detalles Bibliográficos
Autores principales: Jamwal, Sumit, Blackburn, Jennifer K., Elsworth, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540392/
https://www.ncbi.nlm.nih.gov/pubmed/37770961
http://dx.doi.org/10.1186/s13293-023-00551-6