Therapeutic S100A8/A9 blockade inhibits myocardial and systemic inflammation and mitigates sepsis-induced myocardial dysfunction

BACKGROUND AND AIMS: The triggering factors of sepsis-induced myocardial dysfunction (SIMD) are poorly understood and are not addressed by current treatments. S100A8/A9 is a pro-inflammatory alarmin abundantly secreted by activated neutrophils during infection and inflammation. We investigated the e...

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Detalles Bibliográficos
Autores principales: Jakobsson, Gabriel, Papareddy, Praveen, Andersson, Henrik, Mulholland, Megan, Bhongir, Ravi, Ljungcrantz, Irena, Engelbertsen, Daniel, Björkbacka, Harry, Nilsson, Jan, Manea, Adrian, Herwald, Heiko, Ruiz-Meana, Marisol, Rodríguez-Sinovas, Antonio, Chew, Michelle, Schiopu, Alexandru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540409/
https://www.ncbi.nlm.nih.gov/pubmed/37773186
http://dx.doi.org/10.1186/s13054-023-04652-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540409/
https://www.ncbi.nlm.nih.gov/pubmed/37773186
http://dx.doi.org/10.1186/s13054-023-04652-x

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