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Using short-term endpoints to improve interim decision making and trial duration in two-stage phase II trials with nested binary endpoints
In oncology, phase II clinical trials are often planned as single-arm two-stage designs with a binary endpoint, for example, progression-free survival after 12 months, and the option to stop for futility after the first stage. Simon’s two-stage design is a very popular approach but depending on the...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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SAGE Publications
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540486/ https://www.ncbi.nlm.nih.gov/pubmed/37489267 http://dx.doi.org/10.1177/09622802231188515 |