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Two clip-domain serine protease homologs, cSPH35 and cSPH242, act as a cofactor for prophenoloxidase-1 activation in Drosophila melanogaster

Insect phenoloxidases (POs) catalyze phenol oxygenation and o-diphenol oxidation to form reactive intermediates that kill invading pathogens and form melanin polymers. To reduce their toxicity to host cells, POs are produced as prophenoloxidases (PPOs) and activated by a serine protease cascade as r...

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Detalles Bibliográficos
Autores principales: Jin, Qiao, Wang, Yang, Yin, Haodong, Jiang, Haobo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540698/
https://www.ncbi.nlm.nih.gov/pubmed/37781370
http://dx.doi.org/10.3389/fimmu.2023.1244792