Nonviral overexpression of Scleraxis or Mohawk drives reprogramming of degenerate human annulus fibrosus cells from a diseased to a healthy phenotype

BACKGROUND: Intervertebral disc (IVD) degeneration is a major contributor to low back pain (LBP), yet there are no clinical therapies targeting the underlying pathology. The annulus fibrosus (AF) plays a critical role in maintaining IVD structure/function and undergoes degenerative changes such as m...

Descripción completa

Detalles Bibliográficos
Autores principales: Tang, Shirley, Gantt, Connor, Salazar Puerta, Ana, Bodine, Lucy, Khan, Safdar, Higuita‐Castro, Natalia, Purmessur, Devina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540831/
https://www.ncbi.nlm.nih.gov/pubmed/37780832
http://dx.doi.org/10.1002/jsp2.1270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10540831/
https://www.ncbi.nlm.nih.gov/pubmed/37780832
http://dx.doi.org/10.1002/jsp2.1270

Ejemplares similares