Cla4 phosphorylates histone methyltransferase Set1 to prevent its degradation by the APC/C(Cdh1) complex

H3K4 trimethylation (H3K4me3) is a conserved histone modification catalyzed by histone methyltransferase Set1, and its dysregulation is associated with pathologies. Here, we show that Set1 is intrinsically unstable and elucidate how its protein levels are controlled within cell cycle and during gene...

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Detalles Bibliográficos
Autores principales: Gong, Xuanyunjing, Wang, Shanshan, Yu, Qi, Wang, Min, Ge, Feng, Li, Shanshan, Yu, Xilan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541012/
https://www.ncbi.nlm.nih.gov/pubmed/37774018
http://dx.doi.org/10.1126/sciadv.adi7238

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541012/
https://www.ncbi.nlm.nih.gov/pubmed/37774018
http://dx.doi.org/10.1126/sciadv.adi7238

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