Targeting YAP mechanosignaling to ameliorate stiffness-induced Schlemm’s canal cell pathobiology

Pathologic alterations in the biomechanical properties of the Schlemm’s canal (SC) inner wall endothelium and its immediate vicinity are strongly associated with ocular hypertension in glaucoma due to decreased outflow facility. Specifically, the underlying trabecular meshwork is substantially stiff...

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Detalles Bibliográficos
Autores principales: Li, Haiyan, Kuhn, Megan, Kelly, Ruth A., Singh, Ayushi, Palanivel, Kavipriya Kovai, Salama, Izzy, De Ieso, Michael L., Stamer, W. Daniel, Ganapathy, Preethi S., Herberg, Samuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541092/
https://www.ncbi.nlm.nih.gov/pubmed/37781615
http://dx.doi.org/10.1101/2023.09.08.556840

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541092/
https://www.ncbi.nlm.nih.gov/pubmed/37781615
http://dx.doi.org/10.1101/2023.09.08.556840

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