Isofagomine inhibits multiple TcdB variants and protects mice from Clostridioides difficile induced mortality

Clostridioides difficile causes life-threatening diarrhea and is the leading cause of healthcare associated bacterial infections in the United States. During infection, C. difficile releases the gut-damaging toxins, TcdA and TcdB, the primary determinants of disease pathogenesis and are therefore th...

Descripción completa

Detalles Bibliográficos
Autores principales: Paparella, Ashleigh S., Brew, Isabella, Hong, Huynh A., Ferriera, William, Cutting, Simon, Lamiable-Oulaidi, Farah, Popadynec, Michael, Tyler, Peter C., Schramm, Vern L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541099/
https://www.ncbi.nlm.nih.gov/pubmed/37781587
http://dx.doi.org/10.1101/2023.09.19.558375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541099/
https://www.ncbi.nlm.nih.gov/pubmed/37781587
http://dx.doi.org/10.1101/2023.09.19.558375

Ejemplares similares