Cargando…

Isofagomine inhibits multiple TcdB variants and protects mice from Clostridioides difficile induced mortality

Clostridioides difficile causes life-threatening diarrhea and is the leading cause of healthcare associated bacterial infections in the United States. During infection, C. difficile releases the gut-damaging toxins, TcdA and TcdB, the primary determinants of disease pathogenesis and are therefore th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Paparella, Ashleigh S., Brew, Isabella, Hong, Huynh A., Ferriera, William, Cutting, Simon, Lamiable-Oulaidi, Farah, Popadynec, Michael, Tyler, Peter C., Schramm, Vern L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541099/ https://www.ncbi.nlm.nih.gov/pubmed/37781587 http://dx.doi.org/10.1101/2023.09.19.558375

Ejemplares similares

Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues
por: Paparella, Ashleigh S., et al.
Publicado: (2021)

Clostridioides difficile TcdB Toxin Glucosylates Rho GTPase by an S(N)i Mechanism and Ion Pair Transition State
por: Paparella, Ashleigh S., et al.
Publicado: (2022)

Inhibition of Clostridioides difficile Toxins TcdA and TcdB by Ambroxol
por: Heber, Sebastian, et al.
Publicado: (2022)

Putative Conjugative Plasmids with tcdB and cdtAB Genes in Clostridioides difficile
por: Ramírez-Vargas, Gabriel, et al.
Publicado: (2020)

TcdB of Clostridioides difficile Mediates RAS-Dependent Necrosis in Epithelial Cells
por: Stieglitz, Florian, et al.
Publicado: (2022)

Human α-Defensin-5 Efficiently Neutralizes Clostridioides difficile Toxins TcdA, TcdB, and CDT
por: Korbmacher, Michael, et al.
Publicado: (2020)

The Compound U18666A Inhibits the Intoxication of Cells by Clostridioides difficile Toxins TcdA and TcdB
por: Papatheodorou, Panagiotis, et al.
Publicado: (2021)

Human α-Defensin-6 Neutralizes Clostridioides difficile Toxins TcdA and TcdB by Direct Binding
por: Barthold, Lara, et al.
Publicado: (2022)

Neutralising Effects of Different Antibodies on Clostridioides difficile Toxins TcdA and TcdB in a Translational Approach
por: Csukovich, Georg, et al.
Publicado: (2023)

Exploring the inhibitory potential of the antiarrhythmic drug amiodarone against Clostridioides difficile toxins TcdA and TcdB
por: Schumacher, Judith, et al.
Publicado: (2023)

Lectin Activity of the TcdA and TcdB Toxins of Clostridium difficile
por: Hartley-Tassell, Lauren E., et al.
Publicado: (2019)

Development and characterization of phage display-derived anti-toxin antibodies neutralizing TcdA and TcdB of Clostridioides difficile
por: Raeisi, Hamideh, et al.
Publicado: (2023)

CdtR Regulates TcdA and TcdB Production in Clostridium difficile
por: Lyon, Shelley A., et al.
Publicado: (2016)

Ribotype Classification of Clostridioides difficile Isolates Is Not Predictive of the Amino Acid Sequence Diversity of the Toxin Virulence Factors TcdA and TcdB
por: Li, Zhenghui, et al.
Publicado: (2020)

Development of Neutralizing and Non-neutralizing Antibodies Targeting Known and Novel Epitopes of TcdB of Clostridioides difficile
por: Fühner, Viola, et al.
Publicado: (2018)

Novel Biomarkers, Including tcdB PCR Cycle Threshold, for Predicting Recurrent Clostridioides difficile Infection
por: Madden, Gregory R., et al.
Publicado: (2023)

Amino Acid Differences in the 1753-to-1851 Region of TcdB Influence Variations in TcdB1 and TcdB2 Cell Entry
por: Hunt, Jonathan J., et al.
Publicado: (2017)

A Colonic Organoid Model Challenged with the Large Toxins of Clostridioides difficile TcdA and TcdB Exhibit Deregulated Tight Junction Proteins
por: Schneemann, Martina, et al.
Publicado: (2023)

Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection
por: Chen, Peng, et al.
Publicado: (2021)

Variations in TcdB Activity and the Hypervirulence of Emerging Strains of Clostridium difficile
por: Lanis, Jordi M., et al.
Publicado: (2010)

Nectin-3 and shed forms of CSPG4 can serve as epithelial cell receptors for Clostridioides difficile TcdB
por: Childress, Kevin O., et al.
Publicado: (2023)

A DNA vaccine targeting TcdA and TcdB induces protective immunity against Clostridium difficile
por: Zhang, Bao-Zhong, et al.
Publicado: (2016)

Intrinsic Toxin-Derived Peptides Destabilize and Inactivate Clostridium difficile TcdB
por: Larabee, Jason L., et al.
Publicado: (2017)

Plakoglobin and High-Mobility Group Box 1 Mediate Intestinal Epithelial Cell Apoptosis Induced by Clostridioides difficile TcdB
por: Li, Yingxue, et al.
Publicado: (2022)

Receptor Binding Domains of TcdB from Clostridioides difficile for Chondroitin Sulfate Proteoglycan-4 and Frizzled Proteins Are Functionally Independent and Additive
por: Henkel, Daniel, et al.
Publicado: (2020)

Association of tcdA+/tcdB+ Clostridium difficile Genotype with Emergence of Multidrug-Resistant Strains Conferring Metronidazole Resistant Phenotype
por: Shayganmehr, Farahnaz-Sadat, et al.
Publicado: (2015)

Intestine epithelial cell-derived extracellular vesicles alleviate inflammation induced by Clostridioides difficile TcdB through the activity of TGF-β1
por: Wan, Shuangshuang, et al.
Publicado: (2022)

The Role of TcdB and TccC Subunits in Secretion of the Photorhabdus Tcd Toxin Complex
por: Yang, Guowei, et al.
Publicado: (2013)

Study of the frequency of Clostridium difficile tcdA, tcdB, cdtA and cdtB genes in feces of Calves in south west of Iran
por: Doosti, Abbas, et al.
Publicado: (2014)

Defining the Roles of TcdA and TcdB in Localized Gastrointestinal Disease, Systemic Organ Damage, and the Host Response during Clostridium difficile Infections
por: Carter, Glen P., et al.
Publicado: (2015)

Nanobodies against C. difficile TcdA and TcdB reveal unexpected neutralizing epitopes and provide a toolkit for toxin quantitation in vivo
por: Kordus, Shannon L., et al.
Publicado: (2023)

Indeterminate tcdB using a Clostridium difficile PCR assay: a retrospective cohort study
por: Leis, Jerome A, et al.
Publicado: (2013)

Designed Ankyrin Repeat Protein (DARPin) Neutralizers of TcdB from Clostridium difficile Ribotype 027
por: Peng, Zeyu, et al.
Publicado: (2019)

Overexpression of the Endosomal Anion/Proton Exchanger ClC-5 Increases Cell Susceptibility toward Clostridium difficile Toxins TcdA and TcdB
por: Ruhe, Frederike, et al.
Publicado: (2017)

Clostridium difficile 027/BI/NAP1 Encodes a Hypertoxic and Antigenically Variable Form of TcdB
por: Lanis, Jordi M., et al.
Publicado: (2013)

Immunization with Recombinant TcdB-Encapsulated Nanocomplex Induces Protection against Clostridium difficile Challenge in a Mouse Model
por: Liu, Yi-Wen, et al.
Publicado: (2017)

Intestinal bile acids provide a surmountable barrier against C. difficile TcdB-induced disease pathogenesis
por: Icho, Simoun, et al.
Publicado: (2023)

The TcdE holin drives toxin secretion and virulence in Clostridioides difficile
por: DiBenedetto, NV, et al.
Publicado: (2023)

Rapid Quantification of C. difficile Glutamate Dehydrogenase and Toxin B (TcdB) with a NanoBiT Split-Luciferase Assay
por: Adamson, Hope, et al.
Publicado: (2022)

Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities
por: Quesada-Gómez, Carlos, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_vgsglhhj0fo4ha06ugpph1at0g