Antibody gene features associated with binding and functional activity in vaccine-derived human mAbs targeting malaria parasites

Adjuvants have been essential to malaria vaccine development, but their impact on the vaccine-induced antibody repertoire is poorly understood. Here, we used cDNA sequences from antigen-specific single memory B cells to express 132 recombinant human anti-Pfs230 monoclonal antibodies (mAbs). Alhydrog...

Descripción completa

Detalles Bibliográficos
Autores principales: Coelho, Camila H., Marquez, Susanna, Tentokam, Bergeline C. Nguemwo, Berhe, Anne D., Miura, Kazutoyo, Long, Carole A., Sagara, Issaka, Healy, Sara, Kleinstein, Steven H., Duffy, Patrick E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541113/
https://www.ncbi.nlm.nih.gov/pubmed/37781572
http://dx.doi.org/10.1101/2023.08.01.551554

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541113/
https://www.ncbi.nlm.nih.gov/pubmed/37781572
http://dx.doi.org/10.1101/2023.08.01.551554

Ejemplares similares