MYCN driven oncogenesis involves cooperation with WDR5 to activate canonical MYC targets and G9a to repress differentiation genes

MYCN activates canonical MYC targets involved in ribosome biogenesis, protein synthesis and represses neuronal differentiation genes to drive oncogenesis in neuroblastoma (NB). How MYCN orchestrates global gene expression remains incompletely understood. Our study finds that MYCN binds promoters to...

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Detalles Bibliográficos
Autores principales: Liu, Zhihui, Zhang, Xiyuan, Xu, Man, Hong, Jason J., Ciardiello, Amanda, Lei, Haiyan, Shern, Jack F., Thiele, Carol J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541123/
https://www.ncbi.nlm.nih.gov/pubmed/37781575
http://dx.doi.org/10.1101/2023.07.11.548643

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541123/
https://www.ncbi.nlm.nih.gov/pubmed/37781575
http://dx.doi.org/10.1101/2023.07.11.548643

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