De novo designed Hsp70 activator dissolves intracellular condensates

Protein quality control (PQC) is carried out in part by the chaperone Hsp70, in concert with adapters of the J-domain protein (JDP) family. The JDPs, also called Hsp40s, are thought to recruit Hsp70 into complexes with specific client proteins. However, the molecular principles regulating this proce...

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Detalles Bibliográficos
Autores principales: Zhang, Jason Z, Greenwood, Nathan, Hernandez, Jason, Cuperus, Josh T, Huang, Buwei, Ryder, Bryan D, Queitsch, Christine, Gestwicki, Jason E, Baker, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541127/
https://www.ncbi.nlm.nih.gov/pubmed/37781598
http://dx.doi.org/10.1101/2023.09.18.558356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541127/
https://www.ncbi.nlm.nih.gov/pubmed/37781598
http://dx.doi.org/10.1101/2023.09.18.558356

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