Site-Specific Crosslinking Reveals Phosphofructokinase-L Inhibition Drives Self-Assembly and Attenuation of Protein Interactions

Phosphofructokinase is the central enzyme in glycolysis and constitutes a highly regulated step. The liver isoform (PFKL) compartmentalizes during activation and inhibition in vitro and in vivo respectively. Compartmentalized PFKL is hypothesized to modulate metabolic flux consistent with its centra...

Descripción completa

Detalles Bibliográficos
Autores principales: Sivadas, Athira, McDonald, Eli Fritz, Shuster, Sydney O., Davis, Caitlin M., Plate, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541129/
https://www.ncbi.nlm.nih.gov/pubmed/37781627
http://dx.doi.org/10.1101/2023.09.19.558525

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541129/
https://www.ncbi.nlm.nih.gov/pubmed/37781627
http://dx.doi.org/10.1101/2023.09.19.558525

Ejemplares similares