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Systematic Perturbation of Thousands of Retroviral LTRs in Mouse Embryos

In mammals, many retrotransposons are de-repressed during zygotic genome activation (ZGA). However, their functions in early development remain elusive largely due to the challenge to simultaneously manipulate thousands of retrotransposon insertions in embryos. Here, we employed epigenome editing to...

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Detalles Bibliográficos
Autores principales: Yang, Jian, Cook, Lauryn, Chen, Zhiyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541133/
https://www.ncbi.nlm.nih.gov/pubmed/37781606
http://dx.doi.org/10.1101/2023.09.19.558531