Genomic context sensitizes regulatory elements to genetic disruption

Enhancer function is frequently investigated piecemeal using truncated reporter assays or single deletion analysis. Thus it remains unclear to what extent enhancer function at native loci relies on surrounding genomic context. Using the Big-IN technology for targeted integration of large DNAs, we an...

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Detalles Bibliográficos
Autores principales: Ordoñez, Raquel, Zhang, Weimin, Ellis, Gwen, Zhu, Yinan, Ashe, Hannah J., Ribeiro-dos-Santos, André M., Brosh, Ran, Huang, Emily, Hogan, Megan S., Boeke, Jef D., Maurano, Matthew T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541140/
https://www.ncbi.nlm.nih.gov/pubmed/37781588
http://dx.doi.org/10.1101/2023.07.02.547201

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541140/
https://www.ncbi.nlm.nih.gov/pubmed/37781588
http://dx.doi.org/10.1101/2023.07.02.547201

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