Translation of dipeptide repeat proteins in C9ORF72 ALS/FTD through unique and redundant AUG initiation codons

A hexanucleotide repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). A hallmark of ALS/FTD pathology is the presence of dipeptide repeat (DPR) proteins, produced from both sense GGGGCC (poly-GA, poly-GP, poly-GR) and...

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Detalles Bibliográficos
Autores principales: Sonobe, Yoshifumi, Lee, Soojin, Krishnan, Gopinath, Gu, Yuanzheng, Kwon, Deborah Y, Gao, Fen-Biao, Roos, Raymond P, Kratsios, Paschalis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541178/
https://www.ncbi.nlm.nih.gov/pubmed/37675986
http://dx.doi.org/10.7554/eLife.83189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541178/
https://www.ncbi.nlm.nih.gov/pubmed/37675986
http://dx.doi.org/10.7554/eLife.83189

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