Pathogenic myelin-specific antibodies in multiple sclerosis target conformational proteolipid protein 1–anchored membrane domains

B cell clonal expansion and cerebrospinal fluid (CSF) oligoclonal IgG bands are established features of the immune response in multiple sclerosis (MS). Clone-specific recombinant monoclonal IgG1 Abs (rAbs) derived from MS patient CSF plasmablasts bound to conformational proteolipid protein 1 (PLP1)...

Descripción completa

Detalles Bibliográficos
Autores principales: Owens, Gregory P., Fellin, Timothy J., Matschulat, Adeline, Salas, Vanessa, Schaller, Kristin L., Given, Katherine S., Ritchie, Alanna M., Navarro, Andre, Blauth, Kevin, Hughes, Ethan G., Macklin, Wendy B., Bennett, Jeffrey L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541191/
https://www.ncbi.nlm.nih.gov/pubmed/37561592
http://dx.doi.org/10.1172/JCI162731

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541191/
https://www.ncbi.nlm.nih.gov/pubmed/37561592
http://dx.doi.org/10.1172/JCI162731

Ejemplares similares