Gβγ-SNAP25 exocytotic brake removal enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity

Negative regulation of exocytosis from secretory cells is accomplished through inhibitory signals from G(i/o) GPCRs by Gβγ subunit inhibition of 2 mechanisms: decreased calcium entry and direct interaction of Gβγ with soluble N-ethylmaleimide–sensitive factor attachment protein (SNAP) receptor (SNAR...

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Detalles Bibliográficos
Autores principales: Ceddia, Ryan P., Zurawski, Zack, Thompson Gray, Analisa, Adegboye, Feyisayo, McDonald-Boyer, Ainsley, Shi, Fubiao, Liu, Dianxin, Maldonado, Jose, Feng, Jiesi, Li, Yulong, Alford, Simon, Ayala, Julio E., McGuinness, Owen P., Collins, Sheila, Hamm, Heidi E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541194/
https://www.ncbi.nlm.nih.gov/pubmed/37561580
http://dx.doi.org/10.1172/JCI160617

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541194/
https://www.ncbi.nlm.nih.gov/pubmed/37561580
http://dx.doi.org/10.1172/JCI160617

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