Vascular endothelial cell-specific disruption of the profilin1 gene leads to severe multiorgan pathology and inflammation causing mortality

Actin-binding protein Profilin1 is an important regulator of actin cytoskeletal dynamics in cells and critical for embryonic development in higher eukaryotes. The objective of the present study was to examine the consequence of loss-of-function of Pfn1 in vascular endothelial cells (ECs) in vivo. We...

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Detalles Bibliográficos
Autores principales: Allen-Gondringer, Abigail, Gau, David, Varghese, Christopher, Boone, David, Stolz, Donna, Larregina, Adriana, Roy, Partha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Biological, Health, and Medical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541205/
https://www.ncbi.nlm.nih.gov/pubmed/37781098
http://dx.doi.org/10.1093/pnasnexus/pgad305

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541205/
https://www.ncbi.nlm.nih.gov/pubmed/37781098
http://dx.doi.org/10.1093/pnasnexus/pgad305

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