Monoclonal antibodies neutralizing alpha-hemolysin, bicomponent leukocidins, and clumping factor A protected against Staphylococcus aureus-induced acute circulatory failure in a mechanically ventilated rabbit model of hyperdynamic septic shock

BACKGROUND: Patients with septic shock caused by Staphylococcus aureus have mortality rates exceeding 50%, despite appropriate antibiotic therapy. Our objectives were to establish a rabbit model of S. aureus septic shock and to determine whether a novel immunotherapy can prevent or halt its natural...

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Detalles Bibliográficos
Autores principales: Nguyen, Nhu T. Q., Doan, Thien N. M., Sato, Kei, Tkaczyk, Christine, Sellman, Bret R., Diep, Binh An
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541218/
https://www.ncbi.nlm.nih.gov/pubmed/37781371
http://dx.doi.org/10.3389/fimmu.2023.1260627

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541218/
https://www.ncbi.nlm.nih.gov/pubmed/37781371
http://dx.doi.org/10.3389/fimmu.2023.1260627

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