Targeting Toll-like receptor-driven systemic inflammation by engineering an innate structural fold into drugs

There is a clinical need for conceptually new treatments that target the excessive activation of inflammatory pathways during systemic infection. Thrombin-derived C-terminal peptides (TCPs) are endogenous anti-infective immunomodulators interfering with CD14-mediated TLR-dependent immune responses....

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Detalles Bibliográficos
Autores principales: Petruk, Ganna, Puthia, Manoj, Samsudin, Firdaus, Petrlova, Jitka, Olm, Franziska, Mittendorfer, Margareta, Hyllén, Snejana, Edström, Dag, Strömdahl, Ann-Charlotte, Diehl, Carl, Ekström, Simon, Walse, Björn, Kjellström, Sven, Bond, Peter J., Lindstedt, Sandra, Schmidtchen, Artur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541425/
https://www.ncbi.nlm.nih.gov/pubmed/37773180
http://dx.doi.org/10.1038/s41467-023-41702-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541425/
https://www.ncbi.nlm.nih.gov/pubmed/37773180
http://dx.doi.org/10.1038/s41467-023-41702-y

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