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Statistical methods and data visualisation of patient-reported outcomes in early phase dose-finding oncology trials: a methodological review
BACKGROUND: Traditionally, within dose-finding clinical trials, treatment toxicity and tolerability are assessed by clinicians. Research has shown that clinician reporting may have inadequate inter-rater reliability, poor correlation with patient reported outcomes, and under capture the true toxicit...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541462/ https://www.ncbi.nlm.nih.gov/pubmed/37781154 http://dx.doi.org/10.1016/j.eclinm.2023.102228 |