Enhancing Luciferase Activity and Stability through Generative Modeling of Natural Enzyme Sequences

The availability of natural protein sequences synergized with generative artificial intelligence (AI) provides new paradigms to create enzymes. Although active enzyme variants with numerous mutations have been produced using generative models, their performance often falls short compared to their wi...

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Detalles Bibliográficos
Autores principales: Xie, Wen Jun, Liu, Dangliang, Wang, Xiaoya, Zhang, Aoxuan, Wei, Qijia, Nandi, Ashim, Dong, Suwei, Warshel, Arieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541610/
https://www.ncbi.nlm.nih.gov/pubmed/37786693
http://dx.doi.org/10.1101/2023.09.18.558367

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541610/
https://www.ncbi.nlm.nih.gov/pubmed/37786693
http://dx.doi.org/10.1101/2023.09.18.558367

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