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Enhancing Luciferase Activity and Stability through Generative Modeling of Natural Enzyme Sequences
The availability of natural protein sequences synergized with generative artificial intelligence (AI) provides new paradigms to create enzymes. Although active enzyme variants with numerous mutations have been produced using generative models, their performance often falls short compared to their wi...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541610/ https://www.ncbi.nlm.nih.gov/pubmed/37786693 http://dx.doi.org/10.1101/2023.09.18.558367 |